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We have examined the genetic differences between Korean wild mice(Mus musculus spp.) captured in Paju and the several wild-derived strains (CZECH II/Ei, MOLD/Rk, PERA/Cam Ei, SPRET/Bi, WSB/Bi) of mouse in the 10 loci(Akp-1, Car-2, Es-1, Es-2, Es-3, Es-10, Gpi-1, Hbb, Ldr-1, and Trf) of biochemical markers using cellulose acetate membrane electrophoresis. The several inbred strains of mice(A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57BLKS/J, CBA/J, SKH-1/J, KK/HIJ, MRL/MpJ, NOD/LtJ, NON/LtJ, and SJL/J) was also characterized as control. The wild-derived strains of mice showed different phenotypes in all isozyme loci, respectively. There were big differences in the isozyme pattern of 10 loci between Korean wild mice and inbred mice. The phenotype of Korean wild mouse in all biochemical marker genes was identical to those of CZECH II/Ei, but Korean wild mice showed the different pattern of MOLD/Rk in Es-2 and Es-3 locus. These results may suggest that Korean wild mice have a close genetic relationships with CZECH II/Ei. compared to MOLD/Rk originated from Japan. Also Korean wild mice may have a different genetic background with inbred mice. Korean wild mice will valuable as gene pools of mouse and contribute to the expansion of knowledge about the mouse genome.
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